Boron tribromide → 2-Fluoro-3,4-dihydroxybenzaldehyde

HRID 1283898Notes

Reaction equation

[F:1][C:2]1[C:9]([O:10]C)=[C:8]([O:12]C)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].B(Br)(Br)Br>>[F:1][C:2]1[C:9]([OH:10])=[C:8]([OH:12])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 6035882-Fluoro-3,4-dimethoxybenzaldehyde

Product 1

HCID 5933622-Fluoro-3,4-dihydroxybenzaldehyde

Procedure

As outlined in Example 6, 2-fluoroveratraldehyde is treated with boron tribromide to give 2-fluoroprotocatechualdehyde which is dibenzylated to 3,4-dibenzyloxy-2-fluorobenzaldehyde.

Sources & evidence

ORD record: ord-3a338c7666a44dd2a0dc435789c97030
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03976695

Reaction notes

Loading…