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Bis(Chloromethyl) Ether → 1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bis(Chloromethyl) Ether | HCID 10967 | — |
| 反応物 | 2-Fluoro-3,4-dimethoxybenzaldehyde | HCID 603588 | — |
| 反応物 | 1-Fluoro-2,3-dimethoxybenzene | HCID 2758979 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1-(Chloromethyl)-2-fluoro-3,4-dimethoxybenzene | HCID 237411 | — |
反応手順
The 2-fluoroveratraldehyde used as indicated above is prepared as follows: 3-fluoroveratrole is reacted with monochloromethyl ether in glacial acetic acid to give 2-fluoro-3,4-dimethoxybenzyl chloride which is treated with hexamethylenetetramine in chloroform followed by refluxing in 50% acetic acid to yield the 2-fluoroveratraldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03976695 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-698568d1285144f38373b489a08d7a01 |
| 出典メモ | uspto-grants-1976_08 |