HCID 22792281, compound → HCID 21516986, compound

HRID 1283939Notes

Reaction equation

HRID 1283939 reaction equation
C[O:2][C:3](=O)[C@H:4]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[NH:5][C:6](=[O:9])[CH2:7][NH2:8]>CO.N>[CH2:18]([O:17][C:15]([NH:14][CH2:13][CH2:12][CH2:11][CH2:10][CH:4]1[NH:5][C:6](=[O:9])[CH2:7][NH:8][C:3]1=[O:2])=[O:16])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 1

HCID 22792281HCID 22792281, compound

Product 1

HCID 21516986HCID 21516986, compoundYield 13.2%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

The Nα-glycyl-Nε-carbobenzoxy-L-lysine methyl ester prepared as described in Example 1 was dissolved in methanol previously saturated with ammonia (300 ml.) and allowed to stand for 3 days in a sealed flask at ambient temperature. The solvent was removed in vacuo and the residual solid recrystallised from absolute ethanol to give the title compound as colourless needles (1 g.) m.p. 210°C. (Found: C, 59.9; H, 6.7; N, 13.5. C16H21N3O4 requires: C, 60.1; H, 6.5; N, 13.2%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residual solid recrystallised from absolute ethanol

Sources & evidence

ORD record
ord-d2650fbfa63b4ce0b169691bd6d1a5c6
Source dataset
uspto-grants-1976_08
Patent number
US03976773

Reaction notes

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