Diethylcarbamoyl chloride → HCID 12511419, compound

Participants

Reaction Steps

A mixture of 34,4 g ethylene urea and 54,2 g N,N-diethylcarbamyl chloride is heated under nitrogen at 110° for 3 hrs. The reaction mixture is cooled and diluted with 200 ml acetone. It is filtered and the filtrate evaporated off to dryness. The oily product is chromatographed on a column of 450 g of silica gel. The fraction which eluted from 3% methanol in chloroform yields 1-(N,N-diethylcarbamoyl)-2-oxo-tetrahydroimidazole as a colourless oil.

Provenance & Evidence