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Pyridine → 2,3-Dicyano-5-chloro-6-ethylthiopyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Ethanethiol | HCID 6343 | — |
| 反応物 | 5,6-Dichloro-2,3-dicyanopyrazine | HCID 607820 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,3-Dicyano-5-chloro-6-ethylthiopyrazine | HCID 12873754 | 29.4% |
反応手順
2,3-Dicyano-5,6-dichloropyrazine (1.00 g; 0.005 mole) and 0.47 g of ethanethiol were dissolved in 50 ml of acetone. The solution was cooled to -15° to -10° C., and a solution of 0.40 g (0.005 mole) of pyridine in 40 ml of water was added dropwise over the period of 30 minutes. The mixture was worked up in the same way as in Example 26 to afford 0.33 g (yield 29%) of 2,3-dicyano-5-chloro-6-ethylthiopyrazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04259489 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-2fa57c2e3a6e4c388415e2d2b4985a1a |
| 出典メモ | uspto-grants-1981_03 |