HCID 21515491, compound → 3,5-Dimethoxy-4-(2-methylpropyl)benzoic acid

Participants

Reaction Steps

3,5-Dimethoxy-4-isobutyl-benzoyl chloride. Starting from 3-hydroxy-5-methoxy-benzoic acid methyl ester and 3-chloro-2-methyl-propene, 3-(2-methyl-2-propenyloxy)-5-methoxy-benzoic acid methyl ester is obtained. B.p. 148°-50°C/0.4 mmHg. By operating as described under C), 3,5-dimethoxy-4-(2-methylpropenyl)-benzoic acid is prepared. M.p. 159°-61°C (from diethyl ether). This compound is hydrogenated as under D) to give 3,5-dimethoxy-4-isobutyl-benzoic acid. M.p. 160°-62°C (from diethyl ether/light petroleum). The corresponding chloride melts at 48°-50°C (from ligroin upon cooling).

Provenance & Evidence