HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbodiimide → HCID 12944666, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbodiimide | HCID 160435 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-isoleucine | HCID 2724772 | — |
| Reactant | tert-butyl (2S)-2-amino-3-phenylpropanoate | HCID 6931633 | — |
| Product | HCID 12944666 | HCID 12944666 | 90% |
Reaction Steps
In accordance with the carbodiimide method indicated Z-Ile-OH (4) was linked with H-Phe-OtBu (5). By means of subsequent catalytic diacylation of the intermediate benzyloxy-carbonyl-dipeptide ester (4-5a) it was possible to isolate H-Ile-Phe-OtBu (4-5b) with a yield of above 90 %.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03978035 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-425d11d6661a418e8f82938d2e3df9b6 |
| Source note | uspto-grants-1976_08 |