Thionyl Chloride → HCID 54510804, compound

HRID 1284044Notes

Reaction equation

HRID 1284044 reaction equation
S(Cl)([Cl:3])=O.[C:5]([CH:13]([CH3:21])[C:14]([NH:16][CH2:17][C:18](O)=[O:19])=[S:15])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1C=CC=CC=1>[C:5]([CH:13]([CH3:21])[C:14]([NH:16][CH2:17][C:18]([Cl:3])=[O:19])=[S:15])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21515553HCID 21515553, compound

Product 1

HCID 54510804HCID 54510804, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Thionyl chloride (10 g) is added to N-(α-benzoylthiopropionyl)-glycine (5.4 g) suspended in benzene (25 ml), with stirring. The reaction mixture is maintained at room temperature until all the solid has dissolved. The resulting yellow solution is evaporated in vacuo, taken up into benzene and again evaporated until all the remaining thionyl chloride has been removed. The residual oil is dissolved in 15 ml anhydrous chloroform.

Workup

  1. dissolutionhas dissolved
  2. customThe resulting yellow solution is evaporated in vacuo
  3. customagain evaporated until all the remaining thionyl chloride
  4. customhas been removed
  5. dissolutionThe residual oil is dissolved in 15 ml anhydrous chloroform

Sources & evidence

ORD record
ord-85db3910dac649fca0a679af30ae59f9
Source dataset
uspto-grants-1976_08
Patent number
US03978070

Reaction notes

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