Pyridine → 2-chloro-N-(5-methylisoxazol-3-yl)acetamide

Participants

Reaction Steps

To 800 ml of chloroform is added 118 grams (1.12 moles) of 3-amino-5-methylisoxazole followed by 118 grams (1.5 moles) of pyridine. To this solution is added 147 grams (1.3 moles) of chloroacetylchloride with the addition temperature maintained at 0°-10°C. The reaction is then stirred at room temperature for 1 hour, filtered and dried in a vaccum desiccator to give 116 grams (56%) of 3-(chloroacetamido)-5-methylisoxazole, mp 192°-195°C. This material is slightly irritating to the skin and due caution should be exercised.

Provenance & Evidence