Sodium borohydride → HCID 12773888, compound

Participants

Reaction Steps

To a suspension of 1-(1-methyl-1H-tetrazol-5-yl)-thiomethyl- 6,7-dibenzyloxy-3,4-dihydroisoquinoline (1g) in methanol (10 ml) was added sodium borohydride (120 mg), and the mixture was stirred for 1.5 hours at room temperature. After the reaction precipitated crystals were collected by filtration and washed with methanol to give 1-(1-methyl-1H-tetrazol-5-yl)thiomethyl- 6,7-dibenzyloxy-1,2,3,4-tetrahydroisoquinoline (0.88 g). This crystals were recrystallized from ethanol to give crystals, mp 106° to 108°C.

Provenance & Evidence