Imidazole → HCID 56979742, compound

HRID 1284073Notes

Reaction equation

HRID 1284073 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)Cl.[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>C(#N)C>[CH3:1][O:2][C:3](=[O:18])[C:4]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:20]1[NH:19][CH:23]=[CH:22][N:21]=1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 512403154311-64-7

Product 1

HCID 56979742HCID 56979742, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

13 g (0.05 mole) diphenyl-chloroacetic acid methyl ester (b.p. 140°C/0.1 mm Hg, prepared from diphenyl-chloroacetic acid chloride and methanol according to Ber. 22, 1537) are heated with 10 g imidazole in 100 ml acetonitrile at boiling temperature for 18 hours. After distilling off the solvent in a vacuum, 50 ml of water are added and the mixture is extracted with methylene chloride. After drying over sodium sulphate, the solvent is distilled off in a vacuum and the residue recrystallized from a little ethyl acetate. The diphenyl-imidazolyl-acetic acid methyl ester is thus obtained in the form of colourless crystals of m.p. 155°C (with decomposition).

Workup

  1. customfor 18 hours
  2. distillationAfter distilling off the solvent in a vacuum, 50 ml of water
  3. additionare added
  4. extractionthe mixture is extracted with methylene chloride
  5. dry with materialAfter drying over sodium sulphate
  6. distillationthe solvent is distilled off in a vacuum
  7. customthe residue recrystallized from a little ethyl acetate

Sources & evidence

ORD record
ord-28ae7c592a35487abd8b60e8f59a1082
Source dataset
uspto-grants-1976_08
Patent number
US03978069

Reaction notes

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