Imidazole → HCID 54064871, compound

Participants

Reaction Steps

15.45 g (0.05 mole) phenyl-p-chlorophenyl-chloroacetic acid ethyl ester (prepared from p-chlorophenyl-magnesium bromide and benzoyl-formic acid ethyl ester and subsequent treatment with thionyl chloride: b.p. 160°C./0.2 mm Hg) are boiled with 10 g imidazole in 100 ml acetonitrile for 16 hours. After distilling off the solvent, 50 ml of water are added, and the mixture is extracted with methylene chloride. After drying, the solvent is distilled off in a vacuum and the phenyl-p-chlorophenyl-imidazolyl-acetate acid ethyl ester i.e. phenyl-4-chlorophenyl-imidazolyl-acetic acid ethyl ester is obtained in the form of an oil which solidifies after a fairly long time.

Provenance & Evidence