Imidazole → HCID 53964139, compound

HRID 1284078Notes

Reaction equation

HRID 1284078 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH:7]([CH3:9])[CH3:8])Cl)[CH3:2].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>C(#N)C>[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH:7]([CH3:9])[CH3:8])[C:18]1[NH:17][CH:21]=[CH:20][N:19]=1)[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 54472173HCID 54472173, compound

Product 1

HCID 53964139HCID 53964139, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

12 g (0.05 mole) phenyl-isopropyl-chloroacetic acid ethyl ester (b.p. 95°C./0.3 mm Hg) are heated with 10 g imidazole and 100 ml acetonitrile at boiling temperature for 18 hours. After distilling off the solvent in a vacuum, 50 ml of water are added and the mixture is extracted by shaking with methylene chloride. The methylene chloride is dried and distilled off in a vacuum. The phenyl-isopropyl-imidazolyl-acetic acid ethyl ester is thus obtained in the form of an oil.

Workup

  1. customfor 18 hours
  2. distillationAfter distilling off the solvent in a vacuum, 50 ml of water
  3. additionare added
  4. extractionthe mixture is extracted
  5. dry with materialThe methylene chloride is dried
  6. distillationdistilled off in a vacuum

Sources & evidence

ORD record
ord-95c4c1a762d340ed939d0d92fac50f8f
Source dataset
uspto-grants-1976_08
Patent number
US03978069

Reaction notes

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