Imidazole → HCID 68140929, compound

Participants

Reaction Steps

18.1 g diphenyl-chloroacetic acid dimethylamide (m.p. 128°C, prepared by analogy with Example 19) are heated with 15.6 g imidazole in 120 ml acetonitrile at boiling temperature for 18 hours. The solvent is distilled off in a vacuum. After the addition of 70 ml of water, the mixture is extracted with methylene chloride. After drying, the solvent is distilled off in a vacuum and the solid residue is recrystallized from methanol. The diphenyl-imidazolyl-acetic acid dimethyl amide of m.p. 202°C is thus obtained in the form of colourless crystals.

Provenance & Evidence