Imidazole → HCID 57104362, compound

Participants

Reaction Steps

12.7 g (0.05 mole) phenyl-tert.-butyl-chloroacetic acid methyl ester (b.p. 96°C./0.3 mm Hg) are heated to the boil for 17 hours with 10 g imidazole and 100 ml acetonitrile. After the solvent has been distilled off in a vacuum, treatment with 70 ml of water is effected followed by extraction with methylene chloride. The methylene chloride is again extracted with 30 ml of water, dried and distilled off in a vacuum. There is so obtained the phenyl-tert.-butyl-imidazolyl-acetic acid methyl ester as oil, which solidifies after a long time.

Provenance & Evidence