2-Aminopyridine → HCID 12399255, compound

Participants

Reaction Steps

A mixture of 9 g of 2-[4-(chloroacetyl)phenyl]propionamide, 30 ml of ethanol and 7.6 g of 2-aminopyridine is heated under reflux for 2 hours. The ethanol is distilled off under reduced pressure, and water is added to the residue. The crystalline precipitate is filtered off and recrystallized from aqueous dimethylformamide to give 6.9 g of 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionamide as colorless scales melting at 219°-220°C.

Provenance & Evidence