Ethanol → HCID 12399293, compound

Participants

Reaction Steps

A mixture of 5.2 g of ethyl 4-(imidazo[1,2-a]pyridin-2-yl)phenylacetate, 20 ml of ethanol, 0.96 g of sodium hydroxide and 5 ml of water is stirred at room temperature for 10 minutes. The ethanol is distilled off under reduced pressure, and the residue is dissolved in water. The solution is adjusted to pH 6 by addition of dilute hydrochloric acid. The crystalline precipitate is filtered off, washed with water, and recrystallized from ethanol to give 2.3 g of 4-(imidazo[1,2-a]pyridin-2-yl)phenylacetic acid as colorless crystals melting at 217°-221°C with decomposition.

Provenance & Evidence