反应详情

A mixture of 4.4 g of ethyl 2-[4-(imidazo[1,2-a]pyrimidin-2-yl)-phenyl]propionate, 50 ml of ethanol, 0.72 g of sodium hydroxide and 5 ml of water is heated under reflux for 2 hours. The ethanol is distilled off, and acetone is added to the residue. The crystalline precipitate is dissolved in water, and the solution is adjusted to pH 6 by addition of dilute hydrochloric acid. The crystalline precipitate is filtered off and washed with water to give 2.8 g of 2-[4-(imidazo[1,2-a]pyrimidin-2yl)phenyl]propionic acid as colorless crystals melting at 248°C with decomposition.

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. distillationThe ethanol is distilled off
4. additionacetone is added to the residue
5. dissolutionThe crystalline precipitate is dissolved in water
6. additionthe solution is adjusted to pH 6 by addition of dilute hydrochloric acid
7. filtrationThe crystalline precipitate is filtered off
8. washwashed with water