Ethanol → HCID 12399320, compound

Participants

Reaction Steps

A mixture of 5.7 g of ethyl 4-(imidazo[2,1-b]thiazol-6-yl)phenyl-acetate, 25 ml of ethanol, 0.96 g of sodium hydroxide and 5 ml of water is stirred at room temperature for 10 minutes. The ethanol is distilled off under reduced pressure, and the residue is dissolved in water. The solution is adjusted to pH 6 by addition of dilute hydrochloric acid. The crystalline precipitate is filtered off and washed with water to give 2.9 g of 4-(imidazo[2,1-b]thiazol-6-yl)phenylacetic acid as colorless crystals melting at 248°-249°C with decomposition.

Provenance & Evidence