Methylamine → HCID 86733884, compound

Participants

Reaction Steps

A solution of 3.2 g. of 3-hydroxymethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester and 2 g. of methylamine in 30 ml. of benzene is allowed to stir at room temperature overnight. The reaction mixture is concentrated to a foam which is subsequently crystallized twice from ethyl acetate-hexane, 1.95 g., m.p. 154°-156°C. A small sample is again recrystallized from the same solvent system for analysis, m.p. 155°-156°C.

Provenance & Evidence