Butyric Acid → HCID 21515746, compound

Participants

Reaction Steps

A 200 ml- capacity three-necked flask was charged with 78 g of ethyl ortho-acetate, 20 g of 1-pentyn-3-ol and 2.0 g of butyric acid and was heated at 117° to 122°C. and ethanol formed as a by-product was distilled off. Even after completion of the distillation of the ethanol, the mixture was agitated at the above temperature for several hours. After complete extinction of the starting alcohol was confirmed by the gas chromatography, the reaction mixture was subjected to distillation under reduced pressure, and a fraction boiling at 87° to 89.5°C. under 16 mm Hg was collected. The intended ethyl 3,4-heptadienoate was obtained in a yield of 97%.

Provenance & Evidence