Potassium Hydroxide → HCID 21515721, compound

HRID 1284184Notes

Reaction equation

HRID 1284184 reaction equation
[OH-].[K+].C([O:6][CH2:7][CH2:8][CH:9]([CH3:16])[CH2:10][CH2:11][O:12][CH:13]([CH3:15])[CH3:14])(=O)C>CO>[CH:13]([O:12][CH2:11][CH2:10][CH:9]([CH3:16])[CH2:8][CH2:7][OH:6])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 21515697HCID 21515697, compound

Product 1

HCID 21515721HCID 21515721, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

21 g (0.375 mol) of potassium hydroxide are added to 50.5 g (0.25 mol) of 1-acetoxy-5-isopropoxy-3-methylpentane, dissolved in 300 cc of methanol. The mixture is boiled at reflux for 1 hour, concentrated by evaporation to 20 cc at 30°C and 150 cc of water are added. The mixture is extracted with chloroform. The chloroform extract is washed with water, dried with sodium sulphate and evaporated. The residue is distilled at 20 mm Hg. Gas-chromatographically pure 5-isopropoxy-3-methyl-1-pentanol, having a B.P. of 118°-120° /20 mm Hg, is obtained. nD20 = 1.4371.

Workup

  1. temperatureat reflux for 1 hour
  2. concentrationconcentrated by evaporation to 20 cc at 30°C
  3. addition150 cc of water are added
  4. extractionThe mixture is extracted with chloroform
  5. extractionThe chloroform extract
  6. washis washed with water
  7. dry with materialdried with sodium sulphate
  8. customevaporated
  9. distillationThe residue is distilled at 20 mm Hg
  10. customis obtained

Sources & evidence

ORD record
ord-9f6360020f6d4a63aca10055da107ff1
Source dataset
uspto-grants-1976_08
Patent number
US03978097

Reaction notes

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