Hydrogen Bromide → HCID 85822695, compound

Participants

Reaction Steps

A solution of 30 g. (0.14 mole) of 1-cyclopropyl-3-dimethylamino-1-phenyl-1-propanol in 200 ml. of 48% hydrogen bromide was heated at 100°C. for several minutes and then concentrated on a rotating evaporator. The residual oil was dissolved in isopropanol and treated with ether to give an amorphous solid. Recrystallization of the solid from ethyl acetate gave a nearly pure isomer which after additional recrystallization from isopropylmethyl ketone melted at 128°-130°C. The yield was 2.6 g. (5.2%). The nuclear magnetic resonance spectrum showed the double bond to be in position 2 of the hexenylamine.

Provenance & Evidence