Water → HCID 21412090, compound

HRID 1284239Notes

Reaction equation

HRID 1284239 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:16][CH2:17][CH2:18][NH2:19])[C:6]=2[CH:20]=1.O.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([CH2:16][CH2:17][CH2:18][NH:19][C:22](=[O:24])[CH3:23])[C:6]=2[CH:20]=1

Participants

4

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 21412110HCID 21412110, compound

Product 1

HCID 21412090HCID 21412090, compound

Procedure

3-Chloro-5-(3-aminopropyl)-5H-dibenzo[a,d]cycloheptene is dissolved in acetic anhydride and the solution heated to refluxing for 20 minutes. The solution then is cooled and poured into a large volume of water. The mixture is stirred until the excess reagent is hydrolyzed. The product then is extracted into ether, the extract washed with sodium bicarbonate solution, followed by washing with water and dried over sodium sulfate. The product is isolated by evaporating the ether.

Workup

  1. temperaturethe solution heated
  2. temperatureto refluxing for 20 minutes
  3. temperatureThe solution then is cooled
  4. extractionThe product then is extracted into ether
  5. washthe extract washed with sodium bicarbonate solution
  6. washby washing with water
  7. dry with materialdried over sodium sulfate
  8. customThe product is isolated
  9. customby evaporating the ether

Sources & evidence

ORD record
ord-91258c3f4b3f4d0caf79cf8804f315ec
Source dataset
uspto-grants-1976_08
Patent number
US03978121

Reaction notes

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