Sodium Hydroxide → HCID 21515405, compound

HRID 1284327Notes

Reaction equation

HRID 1284327 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[C:7](Cl)[N:6]=[N:5][C:4]=1[NH:10][NH2:11].[OH-].[Na+].[H][H]>CO.[Pd]>[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][N:6]=[N:5][C:4]=1[NH:10][NH2:11]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 218164156-Chloro-3-hydrazinyl-N-methyl-4-pyridazinamineHCID 178418361HCID 178418361, compound

Product 1

HCID 21515405HCID 21515405, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

A solution of 10 g. of 4-methylamino-6-chloro-3-hydrazinopyridazine in 450 ml. of methanol and 150 ml. of 0.5 N sodium hydroxide in methanol are charged into a Paar shaker. To this solution, 2 g. of 10% palladium on carbon is added. The Paar shaker is charged with hydrogen at room temperature to an initial pressure of 50 psi and shaken. After about 6.5 hours, the reaction mixture is filtered, the solvent evaporated and the residue extracted with chloroform. The chloroform solution is evaporated to dryness and the 4-methylamino-3-hydrazinopyridazine obtained is dissolved in methanol. Hydrogen chloride gas is bubbled in, and the 4-methylamino-3-hydrazinopyridazine dihydrochloride (m.p. 247°-251°C.) which precipitates is collected by filtration.

Workup

  1. filtrationthe reaction mixture is filtered
  2. customthe solvent evaporated
  3. extractionthe residue extracted with chloroform
  4. customThe chloroform solution is evaporated to dryness

Sources & evidence

ORD record
ord-7426d49f076d44e882d69dd7aaa80f58
Source dataset
uspto-grants-1976_08
Patent number
US03978057

Reaction notes

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