反应详情

温度

200 °C

A mixture of 14.6 g. of 2-tetralone, 20 g. of p-fluorophenyl magnesium bromide, and 200 ml. of diethyl ether is stirred for four hours and then refluxed for one hour. The mixture is acidified with the addition of 200 ml. of 1N hydrochloric acid, filtered, and extracted with diethyl ether. The extracts are combined, washed with water to neutrality, filtered, dried and evaporated. The residue, containing 2-p-fluorophenyl-3,4-dihydronaphthalene is mixed with 25 g. of 5% palladium-on-charcoal catalyst; the resulting mixture is heated to 200°C for six hours, cooled, diluted with 250 ml. of chloroform, filtered, and evaporated to give 2-p-fluorophenylnaphthalene.

1. additionA mixture of 14.6 g
2. temperaturerefluxed for one hour
3. additionThe mixture is acidified with the addition of 200 ml
4. filtrationof 1N hydrochloric acid, filtered
5. extractionextracted with diethyl ether
6. washwashed with water to neutrality
7. filtrationfiltered
8. customdried
9. customevaporated
10. additionThe residue, containing 2-p-fluorophenyl-3,4-dihydronaphthalene
11. additionis mixed with 25 g
12. temperaturecooled
13. additiondiluted with 250 ml
14. filtrationof chloroform, filtered
15. customevaporated