HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 70589991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Isoamyl Alcohol | HCID 31260 | — |
| Reactant | (RS)-Naproxen methyl ester | HCID 529084 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 70589991 | HCID 70589991 | — |
Reaction Steps
A mixture of 24.4 g. of methyl 6-methoxy-2-naphthyl-α-methylacetate, 25 g. of sodium metal, and 500 ml. of anhydrous iso-amyl alcohol are refluxed for 18 hours. The cooled reaction mixture is acidified by the addition of aqueous IN hydrochloric acid. The product is isolated by diethyl ether extraction to give methyl 6-methoxy-3,4-dihydro-2-naphthyl-α-methylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03978116 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-43f4bf7e51194ad5bd1e37ea0fca2bdb |
| Source note | uspto-grants-1976_08 |