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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1284367Generated: October 29, 2026

6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-one → 6-Methoxynaphthyl-alpha-methylacetic acid

https://huagongshe.com/reaction/1284367

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-oneHCID 75582—
ReactantEthyl 6-methoxynaphthyl-alpha-methylacetateHCID 10422645—
ReactantHCID 178420551HCID 178420551—
Product6-Methoxynaphthyl-alpha-methylacetic acidHCID 90323—

Reaction Steps

Thus, for example, by reacting 6-methoxy-2-tetralone with the triphenylphosphorane derived from ethyl 2-halopropionate, 2,2-(1'-carbethoxyeth-1',1'-ylidene)-6-methoxytetralin is prepared. Dehydrogenation thereof provides ethyl 6-methoxynaphthyl-α-methylacetate which upon hydrolysis affords 6-methoxynaphthyl-α-methylacetic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03978124
Source datasetuspto-grants-1976_08
ORD IDord-e350e6d2720d4cb697435527fc068725
Source noteuspto-grants-1976_08