HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 13537980, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2,4-Dichlorophenyl)-5-(trifluoromethyl)-1h-pyrazole-4-carboxamide | HCID 190470 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 13537980 | HCID 13537980 | — |
Reaction Steps
5-(Trifluoromethyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carboxamide (2.36 grams, 0.073 mole) was suspended in 30 ml of toluene, 10 ml of thionyl chloride, and about 1 ml of DMF. The suspension was stirred and heated to reflux, then refluxed for 11/2 hours. Solvent and excess thionyl chloride was removed in vacuo. The crude solid was crystallized from toluene yielding 5-(trifluoromethyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carbonitrile, yield 0.7 gram, mp=83°-85° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563210 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-a17069991f8c45499ada1b22a6bde433 |
| Source note | uspto-grants-1986_01 |