Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester → HCID 20251497, compound

Participants

Reaction Steps

To a stirring solution of 4-methyl-6-fluoromethyl-2-pyrimidinamine (1.4 mmol) in 25 ml of CH2Cl2 was added o-carbomethoxybenzenesulfonyl isocyanate (1.77 mmol). After stirring 16 hours the reaction was concentrated and the resulting solid washed with butyl chloride to afford 0.28 g of the desired product, m.p. 181°-186° C. NMR (90 MHz, CDCl3): δ 2.5 (s, 3H); 4.0 (s, 3H); 5.2 (s, 1H); 5.7 (s, 1H); 7.0 (s, 1H); 7.6 (m, 3H); 8.2 (m, 1H); 10.3 (s, 1H); 12.8 (br. s, 1H).

Provenance & Evidence