反应详情

A mixture of methyl P-methyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinate (1.5 g, 4.7 mmol) and phosphorus pentasulfide (0.52 g, 1.2 mmol) is heated to 150°-160° under nitrogen for 3-4 hours. After cooling, the residue is purified by preparative thin-layer chromatography (on silica gel, eluting with 20% ethyl acetate/hexane) to give methyl P-methyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinothioate.

1. temperatureis heated to 150°-160° under nitrogen for 3-4 hours
2. temperatureAfter cooling
3. customthe residue is purified by preparative thin-layer chromatography (on silica gel, eluting with 20% ethyl acetate/hexane)