HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-chloro-N-(7-hydroxynaphthalen-1-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 8-Amino-2-naphthalenol | HCID 8358 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-chloro-N-(7-hydroxynaphthalen-1-yl)acetamide | HCID 18621215 | — |
Reaction Steps
The coupling component used in this Example was prepared by chloroacetylating 8-amino-2-naphthol in glacial acetic acid with chloroacetic acid chloride by using sodium acetate as an acid binding agent, to obtain 8-chloroacetylamino-2-naphthol, dissolving isolated 8-chloroacetylamino-2-naphthol in acetone, and then blowing gaseous trimethylamine into the solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563409 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-2490213c38614e2394eb03985afd7015 |
| Source note | uspto-grants-1986_01 |