Droxicam → HCID 13276783, compound

Participants

Reaction Conditions

Reaction Steps

8.1 g (0.02 mols) of 2,4-bis-(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane and 3.6 g (0.01 mol) of 5-methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4-(3H)dione-6,6-dioxide in 80 ml of xylene are maintained under reflux at 140° C. for 36 hours. The mixture is subjected to chromatography over a column containing silica gel as the stationary phase by initially eluting with xylene and then with chloroform. 1.4 g (38%) of 5-methyl-3(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine2(3H)thione-4-one-6,6-dioxide corresponding to the following formula are recovered from the chloroform solution: ##STR9##

Provenance & Evidence