Potassium Sodium Tartrate → HCID 13417327, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (E)-7-phenyl-7-(3-pyridyl)-6-heptenoate (1.5 g, 4.8 mmoles) was dissolved in dry tetrahydrofuran (30 ml) and ice-cooled. Lithium aluminum hydride (0.5 g) was gradually added to the solution. The mixture was stirred at 0° C. for 30 minutes and a saturated aqueous Rochelle salt solution was added to precipiate the inorganic substance. The organic layer was separated and the precipitate was washed with tetrahydrofuran (30 ml). The tetrahydrofuran solutions were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography using ethyl acetate as eluent to give (E)-7-phenyl-7-(3-pyridyl)-6-hepten-1-ol (1.2 g, 94%) (Compound Id-14) as an oil.

Provenance & Evidence