Formic Acid → HCID 86740587, compound

HRID 1284465Notes

Reaction equation

HRID 1284465 reaction equation
[C:1]1(/[C:7](/[C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:8]\[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][OH:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:21](O)=[O:22]>>[CH:21]([O:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]/[CH:8]=[C:7](\[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)/[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:22]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 13417327HCID 13417327, compound

Product 1

HCID 86740587HCID 86740587, compoundYield 91%

Procedure

(E)-7-Phenyl-7-(3-pyridyl)-6-hepten-1-ol (1.2 g, 4.5 mmoles) was added to formic acid (10 ml) and the mixture was refluxed for 7 hours. After cooling, the mixture was concentrated under reduced pressure and the resulting oil was subjected to silica gel column chromatography using isopropyl ether-ethyl acetate (1:1) as the eluent to give 1-formyloxy-(E)-7-phenyl-7-(3-pyridyl)-6-heptene (1.2 g, 91%) (Compound Id-20) as an oil.

Workup

  1. temperaturethe mixture was refluxed for 7 hours
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-45ae4b1cdd1d497695ba7ed70e11bd31
Source dataset
uspto-grants-1986_01
Patent number
US04563446

Reaction notes

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