Phenyl isocyanate → HCID 13423325, compound

Participants

Reaction Steps

(E)-7-Phenyl-7-(3-pyridyl)-6-hepten-1-ol (4 g, 15 mmoles) and phenyl isocyanate (1.6 ml, 15 mmoles) were dissolved in methylene chloride (20 ml), and triethylamine (0.5 ml) was added to the solution. The mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography using isopropyl ether-ethyl acetate (2:1) as the developing solvent and recrystallization of the product from a mixture of ethyl acetate and isopropyl ether gave 1-phenylaminocarbonyloxy-(E)-7-phenyl-7-(3-pyridyl)-6-heptene (3.2 g, 55%)

Provenance & Evidence