p-Toluenesulfonyl isocyanate → HCID 13423329, compound

Participants

Reaction Steps

(E)-7-Phenyl-7-(3-pyridyl)-6-hepten-1-ol (2.0 g, 7.4 mmoles) was dissolved in methylene chloride (20 ml), and p-toluenesulfonyl isocyanate (1.5 g, 7.6 mmoles) was added to the solution. The mixture was stirred at room temperature for an hour and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography using isopropyl ether-ethyl acetate (1:1) as the developing solvent. Recrystallization of the product from ethyl acetate gave 1-(p-toluenesulfonyl)aminocarbonyloxy-(E)-7-phenyl-7-(3-pyridyl)-6-heptene (2.1 g, 60%) (Compound Id-29).

Provenance & Evidence