Water → HCID 13417327, compound

Participants

Reaction Steps

(E)-7-Phenyl-7-(3-pyridyl)-6-hepten-1-ol (2.3 g, 8.6 mmoles) was dissolved in methylene chloride (2.0 ml), and pyridine (1 ml) and p-toluenesulfonyl chloride (1.8 g, 9.4 mmoles) were added. The reaction was allowed to proceed at room temperature overnight, and water (30 ml) was added, followed by extraction of the product with ethyl acetate. The organic layer was washed with water and dried and the solvent was distilled off. The resulting oily product was subjected to silica gel column chromatography using isopropyl ether-ethyl acetate (1:1) as the eluent to give p-toluensulfonate of (E)-7-phenyl-7-(3-pyridyl)-6-hepten-1-ol (3.15 g, 88%) as an oil.

Provenance & Evidence