N-Phenyl-o-phenylenediamine → HCID 20251875, compound

Participants

Reaction Steps

To a solution of 2-anilinoaniline (4.0 g) in a mixture of dichloromethane (20 ml) and pyridine (6.87 g) was dropwise added 4-chlorobutyryl chloride (4.29 g) at 8° C. during a period of 16 minutes. The mixture was stirred at the same temperature for 40 minutes and then diluted with ice-water. The mixture was extracted twice with dichloromethane. The combined extract was washed with 1 N hydrochloric acid and water in turn and dried over magnesium sulfate. The solvent was removed under reduced pressure to give a crystalline residue of 4-chloro-N-(2-anilinophenyl)butyramide (4.3 g).

Provenance & Evidence