p-Toluenesulfonic acid monohydrate → HCID 20251885, compound

Participants

Reaction Steps

A solution of 4-chloro-N-(2-anilinophenyl)butyramide (0.5 g) and p-toluenesulfonic acid monohydrate (33 mg) in toluene (15 ml) was refluxed for 1.5 hours. Toluene was removed under reduced pressure to afford a residue, which was dissolved in dichloromethane (20 ml), washed with a saturated aqueous solution of sodium bicarbonate and water in turn and dried over magnesium sulfate. Removal of the solvent under reduced pressure afforded an oily residue, which was subjected to column chromatography on silica gel (5 g) eluting with a mixture of dichloromethane and ethyl acetate (10:1) to give crystals of 2-(3-chloropropyl)-1-phenyl-1H-benzimidazole (148 mg).

Provenance & Evidence