Thionyl Chloride → HCID 20251885, compound

Participants

Reaction Steps

A solution of 2-(3-hydroxypropyl)-1-phenyl-1H-benzimidazole (1.15 g) and thionyl chloride (0.6 g) in chloroform (23 ml) was refluxed for 1.5 hours. After being cooled, the mixture was diluted with a saturated aqueous solution of sodium bicarbonate. The chloroform layer was washed with water and a saturated aqueous solution of sodium chloride in turn, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to afford 2-(3-chloropropyl)-1-phenyl-1H-benzimidazole (1.0 g).

Provenance & Evidence