Dicyandiamide → HCID 20251869, compound

HRID 1284492Notes

Reaction equation

HRID 1284492 reaction equation
[C:1]([CH2:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=2[N:5]=1)#[N:2].[C:19]([N:21]=[C:22]([NH2:24])[NH2:23])#[N:20].[OH-].[K+]>COCCO>[NH2:20][C:19]1[N:21]=[C:22]([NH2:24])[N:23]=[C:1]([CH2:3][C:4]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:7]3[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=3[N:5]=2)[N:2]=1

Participants

5

Reactant 3

HCID 10005DicyandiamideHCID 14797Potassium HydroxideHCID 12398110(1-Phenyl-1H-benzimidazol-2-yl)acetonitrile

Product 1

HCID 20251869HCID 20251869, compoundYield 73.5%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 2-cyanomethyl-1-phenyl-1H-benzimidazole (1.8 g), dicyanodiamide (785 mg) and potassium hydroxide (87 mg) in methyl cellosolve was refluxed for 2 hours. After the mixture was cooled, the resultant precipitates were filtered off and washed with water and methanol in turn to give 2,4-diamino-6-(1-phenyl-1H-benzimidazol-2-yl)methyl-1,3,5-triazine (1.8 g).

Workup

  1. temperaturewas refluxed for 2 hours
  2. temperatureAfter the mixture was cooled
  3. customthe resultant precipitates
  4. filtrationwere filtered off
  5. washwashed with water and methanol in turn

Sources & evidence

ORD record
ord-eff298e9e81e416abc0e9314a3698dbc
Source dataset
uspto-grants-1986_01
Patent number
US04563455

Reaction notes

Loading…