Ethanol → HCID 178471868, compound

Participants

Reaction Steps

4.5 g of cyclopropylamine are added dropwise to a solution of 24.9 g of ethyl(2-(2,4-dichloro-5-fluorobenzoyl)-3-ethoxy-acrylate in 80 ml of ethanol, while cooling with ice and stirring. When the exothermic reaction has subsided, stirring is continued at room temperature for 1 hour, the solvent is stripped off in vacuo and the residue is recrystallized from cyclohexane/petroleum ether. 22.9 g of ethyl 2-(2,4-dichloro-5-fluoro-benzoyl)-3-cyclopropylamino-acrylate of melting point 89°-90° C. are obtained.

Provenance & Evidence