反应详情

温度

140 °C

A mixture of 2.8 g (0.01 mol) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 3.4 g (0.03 mol) of 2-ethylpiperazine in 15 ml of dimethylsulphoxide is heated at 140° C. for 2 hours. The solution is concentrated under a high vacuum, the residue is heated to 90° C. with 30 ml of water and the precipitate which has separated out is filtered off with suction, washed with methanol and water and isolated. 1.1 g (31% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-ethyl-1-piperazinyl)-3-quinolinecarboxylic acid monohydrate of decomposition point 255°-258° C. are obtained.

1. concentrationThe solution is concentrated under a high vacuum
2. temperaturethe residue is heated to 90° C. with 30 ml of water
3. customthe precipitate which has separated out
4. filtrationis filtered off with suction
5. washwashed with methanol and water
6. customisolated