反应详情

温度

140 °C

A mixture of 2.8 g (0.01 mol) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 1.14 g (0.01 mol) of cis-2,6-dimethylpiperazine and 2.2 g of diazabicyclo-[2,2,2]-octane is heated at 140° C. for 5 hours. The solvent is distilled off under a high vacuum, 30 ml of water are added to the residue, the suspension is adjusted to pH 8 with 2N hydrochloric acid and the precipitate which has separated out is boiled up with 30 ml of methanol. 0.75 g (21% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3,5-dimethyl-1-piperazinyl)-3-quinolinecarboxylic acid of decomposition point 234°-236° C. is obtained.

1. distillationThe solvent is distilled off under a high vacuum, 30 ml of water
2. additionare added to the residue
3. customthe precipitate which has separated out