Ciprofloxacin → HCID 23682893, compound

HRID 1284508Notes

Reaction equation

HRID 1284508 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:20])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:21])[C:6]([C:22]([OH:24])=[O:23])=[CH:5]2)[CH2:3][CH2:2]1.[OH-].[Na+:26]>O>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:20])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:21])[C:6]([C:22]([O-:24])=[O:23])=[CH:5]2)[CH2:2][CH2:3]1.[Na+:26]

Participants

4

Reactant 2

HCID 2764CiprofloxacinHCID 14798Sodium Hydroxide

Product 1

HCID 23682893HCID 23682893, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

68 g of powdered 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid are suspended in 300 ml of water. A solution of 7.7 g of sodium hydroxide in 30 ml of water is added and the mixture is stirred at room temperature for 30 minutes, whereupon most of the carboxylic acid dissolves. The undissolved product is filtered off and rinsed with water and the filtrate is concentrated in vacuo. The yellowish crystalline residue is dried in vacuo at 100° C. Yield: 73.4 g of the sodium salt. Melting point 325° C.

Workup

  1. filtrationThe undissolved product is filtered off
  2. washrinsed with water
  3. concentrationthe filtrate is concentrated in vacuo
  4. customThe yellowish crystalline residue is dried in vacuo at 100° C

Sources & evidence

ORD record
ord-b44fb555b0714f7385af48675ba62a1a
Source dataset
uspto-grants-1986_01
Patent number
US04563459

Reaction notes

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