Ciprofloxacin → HCID 13326837, compound

Participants

Reaction Steps

3.31 g (0.01 mol) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid and 3.9 g of methyl vinyl ketone are heated under reflux in 50 ml of ethanol for 2 hours. The solid is filtered off with suction and washed with methanol to give 2.5 g (62.3% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(3-oxobutyl)-1-piperazinyl]-3-quinolinecarboxylic acid of decomposition point 185°-187° C.

Provenance & Evidence