HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| Reactant | N-[(Dimethylamino)methylene]pyrazine-2-carboxamide | HCID 16727655 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[1-(p-Chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazine | HCID 12850296 | — |
Reaction Steps
To a solution of 12.1 g. of 4-chlorophenylhydrazine hydrochloride in a mixture of 13.5 ml. of 5 N sodium hydroxide, 100 ml. of 30% aqueous acetic acid and 50 ml. of p-dioxane is added 10.0 g. of N-(dimethylaminomethylene)pyrazinecarboxamide. The procedure of Example 2 is then followed giving 3.8 g. of the desired product as tan crystals, mp. 129°-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259504 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-329fadb526ba4417a783d3ae4f2cc47c |
| Source note | uspto-grants-1981_03 |