HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → HCID 13337948, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | 1-Cyclopropyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 185236 | — |
| Product | HCID 13337948 | HCID 13337948 | 75.4% |
Reaction Steps
Analogously to Example 9, 3.45 g of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)-3-quinolinecarboxylic acid (Example B) are reacted with 4.5 g of acrylonitrile to give 3 g of 7-[4-(2-cyanoethyl)-3-methyl-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of melting point 203°-206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563448 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-ce6b6f310fed450aa7b141ba3e6b2119 |
| Source note | uspto-grants-1986_01 |