Methane, dichloromethoxy- → 5-Methoxy-2,3-dihydrobenzofuran-6-carbaldehyde

A solution of 5-methoxy-2,3-dihydrobenzofuran (44.8 g, 299 mmol) in dry methylene chloride (690 mL) was cooled to 3° under nitrogen and titanium tetrachloride (53.5 mL, 92.34 g, 486 mmol) was added dropwise keeping the internal temperature below 7°. To the resulting mixture was added dropwise dichloromethylmethylether (22.3 mL, 28.34 g, 247 mmol) over one hour with the internal temperature maintained at 7°. The cooling bath was removed and the mixture allowed to stir for four hours, then quenched by the dropwise addition of water (120 mL). The resulting mixture was poured into water (100 mL) and the layers separated. The aqueous layer was washed with methylene chloride (2×250 mL), then the combined organic extracts were washed with 5% NaCl (1000 mL), dried (Na2SO4) and concentrated to a dark oil. Purification by preparation HPLC (Waters Prep 500, 15% ethyl acetate in hexane as eluant) afforded 5-methoxy-2,3-dihydrobenzofuran-6-carboxaldehyde as a pale yellow solid (20.64 g, 38.8%), m.p. 82-84° C.

1. customthe internal temperature below 7°
2. temperaturemaintained at 7°
3. customThe cooling bath was removed
4. customquenched by the dropwise addition of water (120 mL)
5. additionThe resulting mixture was poured into water (100 mL)
6. customthe layers separated
7. washThe aqueous layer was washed with methylene chloride (2×250 mL)
8. washthe combined organic extracts were washed with 5% NaCl (1000 mL)
9. dry with materialdried (Na2SO4)
10. concentrationconcentrated to a dark oil
11. customPurification
12. customby preparation HPLC (Waters Prep 500, 15% ethyl acetate in hexane as eluant)

ORD record

ord-b03195387ffb4768b120fa89024b68a0

Source dataset

uspto-grants-1986_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04563476